Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065
…, JP McGovren, MD Prairie, N Wicnienski…
Index: Warpehoski; Gebhard; Kelly; Krueger; Li; McGovren; Prairie; Wicnienski; Wierenga Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 590 - 603
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Citation Number: 144
Abstract
The synthesis, physicochemical properties, and biological activities of a series of novel spiro cyclopropyl compounds, modeled on the potent antitumor antibiotic CC-1065 (l), are described. Many of these synthetic analogues are significantly more effective than 1 against murine tumors. In particular, compound 27 exhibits high activity and potency. Structure- activity analysis supports a molecular mechanism for biological action involving ...
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