Synlett

Dimethyldioxirane Oxidation of 2-Silyloxypyrroles: An Efficient Regiocontrolled Synthesis of 5-Hydroxy-3-pyrrolin-2-ones

J Boukouvalas, Y Xiao, YX Cheng, RP Loach

Index: Boukouvalas, John; Xiao, Yufang; Cheng, Yun-Xing; Loach, Richard P. Synlett, 2007 , # 20 p. 3198 - 3200

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Citation Number: 4

Abstract

Abstract A new method for the synthesis of 5-hydroxy-3-pyrrolin-2-ones is reported. Conversion of N-Boc-3-pyrrolin-2-ones into 2-triisopropylsilyloxypyrroles and ensuing oxidation with dimethyldioxirane provides the corresponding N-Boc-5-hydroxy-3-pyrrolin-2- ones in high yields.

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