2-aminoalchohol immunosuppressants: Structure-activity relationships
R Hirose, N Hamamichi, Y Kitao, T Matsuzaki…
Index: Hirose, Ryoji; Hamamichi, Norimitsu; Kitao, Yuuki; Matsuzaki, Tohru; Chiba, Kenji; Fujita, Tetsuro Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 22 p. 2647 - 2650
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Citation Number: 18
Abstract
The 2-aminoalcohol series of immunosuppressants showed a bell-shaped relationship between the activity and the carbon number. The (R)-isomers were more potent than the (S)- isomers, and (R)-2-aminohexadecanol displayed comparably activity to a potent immunosuppressant, FTY720.
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