Tetrahedron: Asymmetry

Enantiospecific synthesis of some bioactive amino alcohols and related compounds from cyclohexylideneglyceraldehyde

A Sharma, S Chattopadhyay

Index: Sharma, Anubha; Chattopadhyay, Subrata Tetrahedron Asymmetry, 1999 , vol. 10, # 5 p. 883 - 890

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Citation Number: 14

Abstract

Two bioactive amino alcohols or related derivatives, 2-aminohexadecanol I and erythro-9-(2- hydroxy-3-nonyl) adenine hydrochloride (EHNA hydrochloride) IIa, have been synthesized from some enantiomerically pure 3-alkylglycerols. The required C-3 epimeric 3- alkylglycerols were, in turn, prepared by simple Grignard addition to cyclohexylideneglyceraldehyde 1 followed by column chromatography.

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