Synthesis of higher homologs of bifunctional L-lysine derivatives with phage-inactivating effect

M Kondo, K Miyazaki, Y Yada, H Horimoto…

Index: Kondo; Miyazaki; Yada; et al. Agricultural and Biological Chemistry, 1984 , vol. 48, # 5 p. 1263 - 1267

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Citation Number: 5

Abstract

Higher homologs of lysine derivatives consisting of l-lysine and dicarboxylic acids were synthesized. The acids ranged from carbon atoms C11 to C17 and C20 and were coupled with∊-benzyloxycarbonyl-lysine ethyl ester (Lys (Z)-OEt) by conventional methods of peptide synthesis. The removal of the Z-group from the protected compounds by hydrogenation gave the final products as bifunctional agents: undecanedioyl-Lys-OEt, dodecanedioyl-Lys-OEt, ...