Intermolecular Alkene and Alkyne Hydroacylation with β??S??Substituted Aldehydes: Mechanistic Insight into the Role of a Hemilabile P–O–P Ligand

…, H Randell??Sly, SK Brayshaw…

Index: Moxham, Gemma L.; Randell-Sly, Helen; Brayshaw, Simon K.; Weller, Andrew S.; Willis, Michael C. Chemistry - A European Journal, 2008 , vol. 14, # 27 p. 8383 - 8397

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Citation Number: 73

Abstract

Abstract A straightforward to assemble catalytic system for the intermolecular hydroacylation reaction of β-S-substituted aldehydes with activated and unactivated alkenes and alkynes is reported. These catalysts promote the hydroacylation reaction between β-S-substituted aldehydes and challenging substrates, such as internal alkynes and 1-octene. The catalysts are based upon [Rh (cod)(DPEphos)][ClO 4](DPEphos= bis (2-diphenylphosphinophenyl) ...