De novo parallel design, synthesis and evaluation of inhibitors against the reverse transcriptase of human immunodeficiency virus type-1 and drug-resistant variants

…, M Weitman, IO Gleenberg, A Nudelman…

Index: Herschhorn, Alon; Lerman, Lena; Weitman, Michal; Gleenberg, Iris Oz; Nudelman, Abraham; Hizi, Amnon Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2370 - 2384

Full Text: HTML

Citation Number: 35

Abstract

We used molecular modeling to design de novo broad-range inhibitors against wild type and drug-resistant variants of the reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1). First, we screened for small fragments that would interact with each one of four RT structures (one wild type and three mutants). Then, these fragments were linked to build a scaffold molecule. Out of 27 different compounds that were synthesized, four ...