Tetrahedron letters

Synthesis of pyridine-based polyaminocarboxylic ligands bearing a thioalkyl anchor

…, A Favre-Réguillon, S Pellet-Rostaing, M Lemaire

Index: Lin, Yi; Favre-Reguillon, Alain; Pellet-Rostaing, Stephane; Lemaire, Marc Tetrahedron Letters, 2007 , vol. 48, # 19 p. 3463 - 3466

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Citation Number: 8

Abstract

A bicyclic tetraazatriacetic chelating agent containing a thioalkyl pendant group was prepared. Four synthetic routes have been investigated via a Mitsunobu reaction from 2, 4- [bishydroxymethyl]-3-hydroxy-pyridine 1. Deprotection of trityl thioether compound 5c led to ligand 6c in 22% overall yield from the starting 3-hydroxypyridine.