Efficient synthesis of fluorophosphonylated alkyles by ring-opening reaction of cyclic sulfates
SA Diab, A Sene, E Pfund, T Lequeux
Index: Diab, Sonia Amel; Sene, Aboubacary; Pfund, Emmanuel; Lequeux, Thierry Organic Letters, 2008 , vol. 10, # 17 p. 3895 - 3898
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Citation Number: 14
Abstract
ABSTRACT Ring-opening reactions of functionalized 1, 2-cyclic sulfates and oxetanes with the phosphonodifluoromethyl carbanion are reported. This approach allows an easy access to fluorinated β-hydroxyphosphonates that are building blocks in the synthesis of acyclic nucleosides. Synthesis of precursors of nucleoside phosphorylase inhibitors from these alcohols is described.
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