Synthesis of novel fluorinated bisphosphonates and bisphosphonic acids
…, RD Guneratne, AS Modak, DJ Burton
Index: Nair, Haridasan K.; Guneratne, Ranil D.; Modak, Anil S.; Burton, Donald J. Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2393 - 2398
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Citation Number: 29
Abstract
The synthesis of novel fluorinated bisphosphonates with two, three, four, and six difluoromethylene groups (la, lb, 8, 12, and 15)(44-78%) by different approaches is described. The bisphosphonates were converted to the corresponding trimethylsilyl esters which on treatment with deionized water afforded the respective bisphosphonic acids (6, 10, and 14) in good yields.
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