Cinchona Alkaloids in Pneumonia. VII. Amyl and Hydroxyalkyl Apocupreine Ethers
MH Green, AG Renfrew, CL Butler
Index: Green; Renfrew; Butler Journal of the American Chemical Society, 1939 , vol. 61, p. 1783
Full Text: HTML
Citation Number: 0
Abstract
Recent work in the apocupreine ether series3 has shown that on ascending in the series of alkyl ethers, a high pneumococcicidal activity is maintained through the C 4 derivatives. The situation is somewhat complicated by variations in the structure of the butyl group; however, isobutyl apocupreine dihydrochloride was shown to be as active in vitro as the very potent ethyl derivative. This is in marked contrast with the behavior of the corresponding ...
Related Articles:
[Molinaro, Carmela; Jamison, Timothy F. Angewandte Chemie - International Edition, 2005 , vol. 44, # 1 p. 129 - 132]
[Kulkarni, Bheemashankar A.; Sharma, Anubha; Gamre, Sunita; Chattopadhyay, Subrata Synthesis, 2004 , # 4 p. 595 - 599]
Diastereoselective synthesis of functionalized 9-ring ethers (oxonins)
[Brandes, Arndt; Hoffmann, H. M. R. Tetrahedron, 1995 , vol. 51, # 1 p. 145 - 154]