On the reactivity of activated alkynes in copper and solvent-free Huisgen's reaction

…, C Louet, J Herscovici, F Meganem, C Girard

Index: Elamari, Hichem; Jlalia, Ibtissem; Louet, Charlotte; Herscovici, Jean; Meganem, Faouzi; Girard, Christian Tetrahedron Asymmetry, 2010 , vol. 21, # 9-10 p. 1179 - 1183

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Citation Number: 12

Abstract

Terminal alkynes substituted by a carbonyl-type electron-withdrawing group have been found to undergo Huisgen's cycloaddition with azides at room temperature in a solvent-free manner; without a need of either heating or catalysis. Metallic salts, other than the copper ones also efficiently catalyzed the reactions. The yields were good and the products isolated mainly as their 1, 4-disubstituted isomer.

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