Solution Phase Synthesis of an Oligodeoxyribonucleotide Phosphorothioate for Therapeutic Applications

ZS Cheruvallath, AH Krotz, DL Cole…

Index: Cheruvallath; Krotz; Cole; Ravikumar Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1625 - 1628

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Abstract

Abstract: Solution phase synthesis of an oligodeoxyribonucleotide phosphorothioate Octamer ... Recently, considerable attention has been focused on the applications of ... (5'-TTGGGGTT) using phosphorothioate triester method is reported. ... The oligodeoxyribonucleotide phosphorothioate TTGGGGTT (ISIS 5320) is a ... This tetramer inhibits the infection of laboratory-derived isolates of HN-1 and HIV- ... 2 in a variety of phenotypically distinct, ...