Combinatorial synthesis of dihydropyridone libraries and their derivatives

MW Creswell, GL Bolton, JC Hodges, M Meppen

Index: Creswell, Mark W.; Bolton, Gary L.; Hodges, John C.; Meppen, Malte Tetrahedron, 1998 , vol. 54, # 16 p. 3983 - 3998

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Citation Number: 112

Abstract

Polymer-supported quench methodology has been used for parallel purification of combinatorial libraries of dihydropyridones and their derivatives. The dihydropyridone scaffold was assembled via a solution phase Lewis acid catalyzed, herero-Diels-Alder reaction. Further modifications allow for the rapid generation of subsequent aminopiperidine and acyl-aminopiperidine libraries utilizing a library from library approach.