Improved Heteroatom Nucleophilic Addition to Electron-Poor Alkenes Promoted by CeCl3⊙ 7H2O/NaI System Supported on Alumina in Solvent-Free Conditions

…, A Giuliani, E Marcantoni, M Massaccesi…

Index: Bartoli, Giuseppe; Bartolacci, Massimo; Giuliani, Arianna; Marcantoni, Enrico; Massaccesi, Massimo; Torregiani, Elisabetta Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 169 - 174

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Citation Number: 104

Abstract

Conjugate addition of heteroatom nucleophiles to carbon-carbon double bonds conjugated with a strong electron-withdrawing group is one of the most important new bond-forming strategies in synthetic organic chemistry. Among the methods for these Michael additions, Lewis acids have shown the best promoter activity, and in particular, the use of reagents impregnated over inorganic supports is rapidly increased. With the increase of ...