Neue Synthesen für Ibuprofen und Naproxen
EKA Wolber, C Rüchardt
Index: Wolber, Erwin K. A.; Ruechardt, Christoph Chemische Berichte, 1991 , vol. 124, p. 1667 - 1672
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Citation Number: 13
Abstract
A new route for the synthesis of a-arylpropionic acids, in par-isocyanides 3, 10, and these are rearranged by flash pyrolysis ticular for the two most important non-steroidal antiinflam- to a-arylpropionitriles 4, 11 which are converted into a-arylmatory compounds Ibuprofen (5) as well as racemic and op-propionic acids 5, 12 by hydrolysis under standard conditions. tically active Naproxen (12), has been developed. N-(1-Aryl-The intermediate 1-(6- ...
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