Dalton Transactions

A new bis (3-hydroxy-4-pyridinone)-IDA derivative as a potential therapeutic chelating agent. Synthesis, metal-complexation and biological assays

MA Santos, S Gama, L Gano, G Cantinho…

Index: Santos, M. Amelia; Gama, Sofia; Gano, Lurdes; Cantinho, Guilhermina; Farkas, Etelka Dalton Transactions, 2004 , # 21 p. 3772 - 3781

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Citation Number: 15

Abstract

A new bis (3-hydroxy-4-pyridinone) derivative of iminodiacetic acid, imino-bis (acetyl (1-(3′- aminopropyl)-3-hydroxy-2-methyl-4-pyridinone)), IDAPr (3, 4-HP) 2, has been prepared and studied in its interaction with a set of hard metal ions. This tetradentate ligand presents a much higher chelating efficiency for trivalent hard metal ions (Fe, Ga, Al) than the monodentate derivative Deferriprone, namely at the diluted conditions prevailing in ...

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