Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4 (1H)-pyridinones: orally active iron chelators with clinical …

…, AD Hall, PD Taylor, P Sarpong, JB Porter…

Index: Dobbin; Hider; Hall; Taylor; Sarpong; Porter; Xiao; Van der Helm Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2448 - 2458

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Citation Number: 198

Abstract

The synthesis of a range of novel bidentate ligands containing the chelating moiety 3- hydroxy-4 (1H)-pyridinone is described. The pKa values of the ligands and the stability constants of their iron (II1) complexes have been determined. The crystal structures of one of the ligands and one of the iron (II1) complexes are presented. The distribution coefficients of the ligands are reported and are related to the ability of the ligands to remove iron from ...