DNA sequence selectivity of hairpin polyamide turn units

ME Farkas, BC Li, C Dose, PB Dervan

Index: Farkas, Michelle E.; Li, Benjamin C.; Dose, Christian; Dervan, Peter B. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 14 p. 3919 - 3923

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Citation Number: 17

Abstract

A class of hairpin polyamides linked by 3, 4-diaminobutyric acid, resulting in a β-amine residue at the turn unit, showed improved binding affinities relative to their α-amino-γ-turn analogs for particular sequences. We incorporated β-amino-γ-turns in six-ring polyamides and determined whether there are any sequence preferences under the turn unit by quantitative footprinting titrations. Although there was an energetic penalty for G· C and C· ...