Highly Efficient Synthesis of Quinoxalinone-N-oxide via Tandem Nitrosation/Aerobic Oxidative C–N Bond Formation
Y Kobayashi, M Kuroda, N Toba, M Okada…
Index: Kobayashi, Yusuke; Kuroda, Mami; Toba, Natsuki; Okada, Mari; Tanaka, Rie; Kimachi, Tetsutaro Organic Letters, 2011 , vol. 13, # 23 p. 6280 - 6283
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Citation Number: 9
Abstract
An efficient method for constructing quinoxalinone-N-oxides from cyanoacetanilides has been developed. This transformation can be achieved using inexpensive reagents and molecular oxygen under mild conditions, thus offering a practical pathway to quinoxalinone- containing pharmaceuticals such as ataquimast and opaviraline.
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