Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation
P Singh, A Bhardwaj
Index: Singh, Palwinder; Mittal, Anu; Kaur, Satwinderjeet; Holzer, Wolfgang; Kumar, Subodh Organic and Biomolecular Chemistry, 2008 , vol. 6, # 15 p. 2706 - 2712
Full Text: HTML
Citation Number: 28
Abstract
Rationally designed tetrahydropyrans (THPs) carrying one, two, or three aryl rings and other substituents were synthesized by the allylation of β-hydroxy ketones followed by iodocyclization. It has been observed that compounds with one aryl ring on THP are
Related Articles:
Reduction of unsymmetrical benzils using sodium dithionite
[Heilmann, Steven M.; Rasmussen, Jerald K.; Smith, Howell K. Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 987 - 992]
An eco-friendly method for synthesis of symmetrical and unsymmetrical benzoin derivatives
[Safari, Javad; Arani, Naimeh Moshtael; Isfahani, Anousheh Ramezan Asian Journal of Chemistry, 2011 , vol. 23, # 2 p. 495 - 498]
[Sekine, Mitsuo; Nakajima, Masashi; Hata, Tsujiaki Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 1 p. 218 - 223]
[Sklute, Genia; Oizerowich, Rachel; Shulman, Hagit; Keinan, Ehud Chemistry - A European Journal, 2004 , vol. 10, # 9 p. 2159 - 2165]
[Buck; Ide Journal of the American Chemical Society, 1931 , vol. 53, p. 2350,2353]