Benzimidazole derivatives: synthesis, leishmanicidal effectiveness, and molecular docking studies

A Shaukat, HM Mirza, AH Ansari, M Yasinzai…

Index: Shaukat, Awais; Mirza, Hira M.; Ansari, Amna H.; Yasinzai, Masoom; Zaidi, Sohail Z.; Dilshad, Sana; Ansari, Farzana L. Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3606 - 3620

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Citation Number: 13

Abstract

Abstract Leishmanolysin GP63 is a zinc metalloprotease, expressed at the surface of Leishmania promastigotes. Studies on this protein are hindered as only a limited number of effective non-toxic inhibitors of this drug target are known. Present study describes the identification of a variety of 2-aryl-and 5-nitro-2-arylbenzimidazoles as new GP63 inhibitors. All the compounds were tested for in vitro activity against the promastigote form of ...

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