Stereoselective reduction of N-hydroxy-α-iminocarbonyl-oligopeptide methyl esters with Zn–MsOH
N Kise, S Takaoka, M Yamauchi, N Ueda
Index: Kise, Naoki; Takaoka, Shuji; Yamauchi, Masahiro; Ueda, Nasuo Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7297 - 7300
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Citation Number: 4
Abstract
The reduction of N-hydroxy-α-imino esters with Zn–MsOH in THF afforded α-amino esters in high yields. The reduction of N-hydroxy-α-iminocarbonyl-oligopeptide methyl esters prepared from l-phenylalanine and l-leucine di-, tri-, tetrapeptides gave the corresponding S- formed oligopeptide methyl esters in moderate diastereoselectivities.
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