Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus
IO Donkor, ML Sanders
Index: Donkor; Sanders, M. Lee Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 19 p. 2647 - 2649
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Citation Number: 23
Abstract
The reported diketopiperazine calpain inhibitor, cis-ll-3, 6-bis-(4-hydroxybenzyl)-1, 4- dimethylpiperazine-2, 5-dione 1, and its analogues 3 and 4 were synthesized from the corresponding amino acids. The previously assigned structure of 1 is confirmed but neither synthetic 1 nor its N-methylphenylalanine analogues 3 and 4 inhibit porcine erythrocyte calpain I.
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