Synthesis of 5??Radioiodoarabinosyl Uridine Analog for Probing the HSV??1 Thymidine Kinase Gene

KI Lin, LW Chiang, CH Wu, SW Chen…

Index: Lin, Kun-I.; Chiang, Li-Wu; Wu, Chien-Hung; Chen, Shao-Wei; Yu, Chung-Shan Journal of the Chinese Chemical Society, 2007 , vol. 54, # 2 p. 563 - 568

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Citation Number: 3

Abstract

Abstract Tumor cells transduced with herpes simplex virus thymidine kinase gene have been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facile preparation of 5-[125 I] iodoarabinosyl uridine starting from commercially available uridine is reported herein.