Catalytic, Asymmetric Synthesis of 1, 4??Benzoxazinones: A Remarkably Enantioselective Route to α??Amino Acid Derivatives from o??Benzoquinone Imides

…, CJ Abraham, C Dogo??Isonagie…

Index: Wolfer, Jamison; Bekele, Tefsit; Abraham, Ciby J.; Dogo-Isonagie, Cajetan; Lectka, Thomas Angewandte Chemie - International Edition, 2006 , vol. 45, # 44 p. 7398 - 7400

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Citation Number: 63

Abstract

Molecules that serve as versatile branch points for the synthesis of pharmaceutically or biologically active products, besides being of interest in their own right, are especially valuable targets for asymmetric catalysis. The 1, 4-benzoxazinone [1] and 1, 4-benzoxazine [2] systems are intriguing because they are present in clinically significant pharmaceuticals and other biologically active molecules. On the basis of previous success in the ...