Controlling diastereoselectivity in the reactions of enantiomerically pure α-bromoacyl-imidazolidinones with nitrogen nucleophiles: substitution reactions with retention …
NR Treweeke, PB Hitchcock, DA Pardoe…
Index: Treweeke; Hitchcock; Pardoe; Caddick Chemical Communications, 2005 , # 14 p. 1868 - 1870
Full Text: HTML
Citation Number: 1
Abstract
From a synthetic perspective there are still limitations to the aforementioned DKR method for making α-substituted carboxylic acid derivatives. The most obvious is that if access to both diastereoisomers of a substitution product is required then, in general, access to both enantiomers of the chiral auxiliary is required. In this paper we describe a method which avoids this limitation, providing a simple route to either diastereomer (and hence enantiomer) of an amine-substituted ...
Related Articles:
[Trimble, Laird A.; Vederas, John C. Journal of the American Chemical Society, 1986 , vol. 108, # 20 p. 6397 - 6399]
[Williams; Im Journal of the American Chemical Society, 1991 , vol. 113, # 24 p. 9276 - 9286]
[Shah; Schafer; Recchia; Polach; LeMaster Tetrahedron Letters, 1994 , vol. 35, # 1 p. 29 - 32]
Chemo??Enzymatic Synthesis of Optically Active Amino Acids and Peptides
[Chen, Shui-Tein; Wang, Kung-Tsung Journal of the Chinese Chemical Society, 1999 , vol. 46, # 3 p. 301 - 311]
Chemo??Enzymatic Synthesis of Optically Active Amino Acids and Peptides
[Chen, Shui-Tein; Wang, Kung-Tsung Journal of the Chinese Chemical Society, 1999 , vol. 46, # 3 p. 301 - 311]