Rapid Microwave-Assisted Solution Phase Synthesis of 6, 8-Disubstituted 2-Phenyl-3-(substituted-benzothiazol-2-yl)-4-[3 H]-quinazolinones as Novel Anticonvulsants

SS Laddha, SP Bhatnagar

Index: Laddha, Sachin S.; Bhatnagar, Satyendra P. Phosphorus, Sulfur and Silicon and the Related Elements, 2008 , vol. 183, # 9 p. 2262 - 2273

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Citation Number: 13

Abstract

A fast and highly efficient microwave accelerated solution phase procedure for the synthesis of a series of 2-phenyl-3-(benzothiazol-2-yl)-4 [3H]-quinazolinones, substituted in the benzothiazole ring, is developed. The title compounds were characterized by elemental analyses, IR, 1H NMR, and EI-MS data. The anticonvulsant activity of all the new compounds (3a-m and 4a-m) was evaluated against Maximum Electroshock (MES) ...