TMP-zincate as highly chemoselective base for directed ortho metalation
…, M Shilai, M Uchiyama, T Sakamoto
Index: Kondo, Yoshinori; Shilai, Manabu; Uchiyama, Masanobu; Sakamoto, Takao Journal of the American Chemical Society, 1999 , vol. 121, # 14 p. 3539 - 3540
Full Text: HTML
Citation Number: 273
Abstract
Since the pioneering work by Gilman and Wittig, 1 the directed ortho metalation reaction has been widely used as a powerful and efficient method for regioselective functionalization of aromatic compounds. 2 Various directing groups have been employed for facilitating the deprotonation of arenes, and various strong bases such as alkyllithiums or lithium dialkylamides have been employed. The ester group has been regarded as an important ...
Related Articles:
[Bissember, Alex C.; Banwell, Martin G. Journal of Organic Chemistry, 2009 , vol. 74, # 13 p. 4893 - 4895]
New Syntheses of Substituted Pyridines via Bromine–Magnesium Exchange
[Trecourt, Francois; Breton, Gilles; Bonnet, Veronique; Mongin, Florence; Marsais, Francis; Queguiner, Guy Tetrahedron, 2000 , vol. 56, # 10 p. 1349 - 1360]
Preparation and reactions of pyridinyl tellurides
[Shilai; Uchiyama; Kondo; Sakamoto Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 2 p. 481 - 484]
One-pot iodination of hydroxypyridines
[Maloney, Kevin M.; Nwakpuda, Emily; Kuethe, Jeffrey T.; Yin, Jingjun Journal of Organic Chemistry, 2009 , vol. 74, # 14 p. 5111 - 5114]
Acid-mediated halogen exchange in heterocyclic arenes: A highly effective iodination method
[Wolf, Christian; Tumambac, Gilbert E.; Villalobos, Cristina N. Synlett, 2003 , # 12 p. 1801 - 1804]