New Syntheses of Substituted Pyridines via Bromine–Magnesium Exchange
F Trécourt, G Breton, V Bonnet, F Mongin, F Marsais…
Index: Trecourt, Francois; Breton, Gilles; Bonnet, Veronique; Mongin, Florence; Marsais, Francis; Queguiner, Guy Tetrahedron, 2000 , vol. 56, # 10 p. 1349 - 1360
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Citation Number: 133
Abstract
Bromine–magnesium exchange using iPrMgCl in THF at room temperature on 2-, 3-and 4- bromopyridines allowed the synthesis of various functionalized pyridines. The methodology was successfully used for the synthesis of 4-azaxanthone. Moreover, single exchange reactions observed on 2, 6-, 3, 5-, 2, 3-and 2, 5-dibromopyridines, with complete regioselectivity in the case of 2, 3-and 2, 5-dibromopyridines, afforded substituted ...
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