Synthesis

Reactions of 1, 4-benzodiazepinic n-nitrosoamidines with tosylmethyl isocyanide: A novel synthesis of midazolam

C del Pozo, A Macias, E Alonso, J Gonzalez

Index: Synthesis, , # 16 p. 2697 - 2703

Full Text: HTML

Citation Number: 2

Abstract

... 1:1) afforded the desulfonylated compound (3) in 74% yield (Scheme [3] ). [23] The overall process from the starting amide 4a gave 38% yield and constitutes an alternative synthesis of midazolam ... Calcd for C 16 H 12 Cl 2 N 4 O: C, 55.35; H, 3.48; N, 16.14. ... p.65; 40-3a Archer GA ...