Synthesis

Reactions of 1, 4-benzodiazepinic n-nitrosoamidines with tosylmethyl isocyanide: A novel synthesis of midazolam

C del Pozo, A Macias, E Alonso, J Gonzalez

Index: Del Pozo, Carlos; Macias, Alberto; Alonso, Eduardo; Gonzalez, Javier Synthesis, 2004 , # 16 p. 2697 - 2703

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Citation Number: 2

Abstract

Abstract Reaction of 1, 4-benzodiazepinic N-nitrosoamidines, used as synthetic equivalents of imidoyl chlorides, with the mono-anion of tosylmethyl isocyanide is described. The process gives entry to 3-(4-tosyl) imidazo [1, 5-a][1, 4] benzodiazepines, compounds which have not been described yet in the literature. These systems can be derivatized to the corresponding trisubstituted 1, 4-benzodiazepines by alkylation or acylation of the ...