Molecular recognition of xanthine alkaloids: First synthetic receptors for theobromine and a series of new receptors for caffeine

S Goswami, AK Mahapatra, R Mukherjee

Index: Goswami, Shyamaprosad; Mahapatra, Ajit Kumar; Mukherjee, Reshmi Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 20 p. 2717 - 2726

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Citation Number: 31

Abstract

Synthetic receptors (H3, H4, H5 and H6) are designed and synthesised for the first time for theobromine, a xanthine alkaloid used as a diuretic. The synthesis of the receptor H6 is achieved by Co (PPh3) 3Cl-mediated homocoupling of 3-(ethoxycarbonyl) benzyl bromide 12 under mild conditions. New caffeine receptors (H7, H8 and H9) are designed and synthesised. The binding results of theobromine and caffeine (both by NMR and UV ...