Synthesis and fast-atom-bombardment-mass spectrometry of N-acetylmuramoyl-l-alanyl-d-isoglutamine (MDP)
LR Phillips, O Nishimura, BA Fraser
Index: Phillips, Lawrence R.; Nishimura, Osamu; Fraser, Blair A. Carbohydrate Research, 1984 , vol. 132, p. 275 - 286
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Citation Number: 5
Abstract
Abstract N-Acetylmuramoyl-l-alanyl-d-isoglutamine (MDP) was synthesized by a series of condensations of appropriate reagents, followed by hydrogenolysis. Each intermediate step resulted in a stable, crystalline product. d-Isoglutamine 4-benzyl ester was condensed with N-(tert-butoxycarbonyl)-l-alanine N-hydroxysuccinimide ester, to give N-(tert- butoxycarbonyl)-l-alanyl-d-isoglutamine benzyl ester. Condensation of l-alanyl-d- ...
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