Synthesis of muramyl dipeptide analogs with enhanced adjuvant activity.

S Kobayashi, T Fukuda, H Yukimasa, M Fujino…

Index: Kobayashi; Fukuda; Yukimasa; et al. Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 9 p. 2570 - 2577

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Citation Number: 32

Abstract

N-Acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and thirteen new analogs were synthesized by the conventional organic chemical procedure using dicyclohexylcarbodiimide-N-hydroxy-5-norbornene-2, 3-dicarboximide as a coupling agent. Their ability to induce delayed-type hypersensitivity to N-acetyl-3-(4-arsonophenylazo)-L- tyrosine in guinea pigs was assayed. The results indicate that the presence of an α-amino ...

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