A novel and efficient route for the preparation of atorvastatin
J Gao, YH Guo, YP Wang, XJ Wang, WS Xiang
Index: Gao, Jian; Guo, Yang Hui; Wang, Ya Ping; Wang, Xiang Jing; Xiang, Wen Sheng Chinese Chemical Letters, 2011 , vol. 22, # 10 p. 1159 - 1162
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Citation Number: 8
Abstract
A novel and efficient synthetic method of atorvastatin was described. The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner–Wadsworth–Emmons reaction, resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C. This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.
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