Vinca alkaloids in superacidic media: a method for creating a new family of antitumor derivatives

…, JC Jacquesy, C Berrier, MP Jouannetaud…

Index: Fahy; Duflos; Ribet; Jacquesy; Berrier; Jouannetaud; Zunino Journal of the American Chemical Society, 1997 , vol. 119, # 36 p. 8576 - 8577

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Citation Number: 137

Abstract

Vinca alkaloids have been widely used in cancer chemotherapy for over 30 years. 1 Extensive chemistry research has led to several total syntheses, 2 and numerous derivatives have been evaluated, with the aim of improving the therapeutic potency of this class. 3 However, only four drugs are currently available worldwide, namely vinblastine (1a), vincristine (1b), a semisynthetic amide related to vinblastine, vindesine4 (1c, Scheme 1), ...