5-Nitrofuran-2-yl derivatives: synthesis and inhibitory activities against growing and dormant mycobacterium species
…, P Yogeeswari, P Dhakla, P Senthilkumar…
Index: Sriram, Dharmarajan; Yogeeswari, Perumal; Dhakla, Prathiba; Senthilkumar, Palaniappan; Banerjee, Debjani; Manjashetty, Thimmappa H. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1152 - 1154
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Citation Number: 28
Abstract
Eighteen 5-nitrofuran-2-yl derivatives were prepared by reacting 5-nitro-2-furfural with various (sub) phenyl/pyridyl thiosemicarbazide using microwave irradiation. The compounds were tested for their in vitro activity against tubercular and various non-tubercular mycobacterium species in log-phase and 6-week-starved cultures. Compound N-(3, 5- dibromopyridin-2-yl)-2-((5-nitrofuran-2-yl) methylene) hydrazinecarbothioamide (4r) was ...
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