Synthesis and molecular modeling of 1-phenyl-1, 2, 3, 4-tetrahydroisoquinolines and related 5, 6, 8, 9-tetrahydro-13bH-dibenzo [a, h] quinolizines as D1 dopamine …

DL Minor, SD Wyrick, PS Charifson…

Index: Minor, Deborah L.; Wyrick, Steven D.; Charifson, Paul S.; Watts, Val J.; Nichols, David E.; Mailman, Richard B. Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4317 - 4328

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Citation Number: 62

Abstract

New 1-phenyl-1, 2, 3, 4-tetrahydroisoquinolines and related 5, 6, 8, 9-tetrahydro-l3bH- dibenzo [a, hl-quinolizines were prepared as ring-contracted analogs of the prototypical l- phenyl-2, 3, 4, 5-tetrahydrobenzazepines (eg, SCH23390) as a continuation of our studies to characterize the antagonist binding pharmacophore of the D1 dopamine receptor. Receptor affinity was assessed by competition for [3HlSCH23390 binding sites in rat striatal ...