(.+-.)-(Aminoalkyl) benzazepine Analogs: Novel Dopamine D1 Receptor Antagonists

JH Shah, S Izenwasser, B Geter-Douglass…

Index: Shah; Izenwasser; Geter-Douglass; Witkin; Newman Journal of medicinal chemistry, 1995 , vol. 38, # 21 p. 4284 - 4293

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Citation Number: 24

Abstract

Compounds 7a {(f)-7-Chloro-8-hydroxy-3-[4-~ N, N-dimethylamino) butyl]-l-phenyl-2, 3, 4, 5- tetrahydro-lH-3-benzazepine), 11 {(f)-7-chloro-8-hydroxy-3-[6-[(N, N-dimethylamino) hexyl]- lphenyl-2, 3, 4, 5-tetrahydro-lH-3-benzazepine-cyanoborane}, and 15 were moderately potent dopamine D1 receptor antagonists as evidenced by their ability to block dopamine- stimulated adenylyl cyclase activity in rat caudate (predicted Ki values= 60, 34, and 21 nM, ...