Study on disulfur-backboned nucleic acid: Part 2. Efficient synthesis of 3', 5'-dithiothymidine
H Wang, C Cheng, H Zheng, X Liu, C Fang, S Xu…
Index: Wang, Hua; Cheng, Changmei; Zheng, Hongchao; Liu, Xiaohong; Fang, Chang; Xu, Shanshan; Zhao, Yufen Chemistry Letters, 2005 , vol. 34, # 3 p. 432 - 433
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Citation Number: 7
Abstract
A novel and convenient procedure for synthesizing 3′, 5′-dithiothymidine was described. In this procedure, DBU was used to form the intramolecular ring of 2, 3′-anhydrothymidine and then the thioacetic acid was used as solvent as well as the nucleophilic reagent to produce S-acetyl-3′-thiothymidine. A very efficient deprotection step was applied to afford the target compound, which can avoid the oxidization of the thiol groups. And the key ...
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