Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. XVI. Demethylation of 2'-Methoxyacetophenones with Anhydrous Aluminum Chloride or Bromide …

Y Kawamura, H Takatsuki, F Torii, T Horie

Index: Kawamura; Takatsuki; Torii; Horie Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 2 p. 511 - 515

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Citation Number: 19

Abstract

Demethylation of 2′-methoxyacetophenones with anhydrous aluminum chloride in acetonitrile was studied to survey its scope and limitations. The mechanism which the reaction proceeds via sterically constrained intermediates was proposed from the substituent effects. Additionally, dealkylation of 2′-benzyloxy-, 2′-ethoxy-, and 2′- isopropoxyacetophenones with two demethylating reagents, hydrochloric acid in acetic ...