Synthesis of monoazacrown ethers under phase-transfer catalysis
NG Luk'yanenko, SS Basok, EY Kulygina…
Index: Luk'yanenko; Basok; Kulygina, E. Yu.; Bogashchenko, T. Yu.; Yakovenko Russian Journal of Organic Chemistry, 2012 , vol. 48, # 10 p. 1345 - 1352 Zh. Org. Khim., 2012 , vol. 48, # 10 p. 1350 - 1357,8
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Abstract
Abstract A procedure has been proposed for the synthesis of monoazacrown ethers by reaction of N-benzyldiethanolamine with oligo (ethylene glycol) bis-p-toluenesulfonates in a two-phase system aromatic hydrocarbon-50% aqueous alkali, followed by removal of the benzyl group by catalytic hydrogenolysis. The maximal yields of N-benzylaza-12-crown-4,- 18-crown-6, and-21-crown-7 were achieved by adding 4–10 equiv of LiCl, BaBr 2, and ...
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