Effect of crown ether ring size on binding and fluorescence response to saxitoxin in anthracylmethyl monoazacrown ether chemosensors

…, JB Thorne, JS Pharr, RE Gawley

Index: Mao, Hua; Thorne, John B.; Pharr, Jennifer S.; Gawley, Robert E. Canadian Journal of Chemistry, 2006 , vol. 84, # 10 p. 1273 - 1279

Full Text: HTML

Citation Number: 6

Abstract

Convenient macrocyclization synthetic routes for the preparation of different-sized monoaza anthracylmethyl crown ether chemosensors (15-crown-5, 18-crown-6, 21-crown-7, 24-crown- 8, and 27-crown-9) are described. Evaluation of these crowns as chemosensors for saxitoxin revealed that the larger crowns have moderately higher binding constants, with the 27- crown-9 chemosensor having the largest binding constant (2.29× 105 (mol/L)-1). ...