Journal of the American Chemical Society

Enantioselective total synthesis of miroestrol

EJ Corey, LI Wu

Index: Corey; Wu Journal of the American Chemical Society, 1993 , vol. 115, # 20 p. 9327 - 9328

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Citation Number: 80

Abstract

The Thai medicinal plant Pueraria mirifica (Thai kwao keur), which has a fascinating history in the folk medicine of southeast Asia, contains the unusual estrogenic phenol miroestrol (l), first isolated more than fifty years ago. I4 The assignment of structure (without absolute configuration) was made in 1960 on the basis of X-ray diffraction~ tudies.~ The synthesis of miroestrol has remained since that time as a classical unsolved problem, despite a ...