Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors

Y Satoh, JL Stanton, AJ Hutchison…

Index: Satoh; Stanton; Hutchison; Libby; Kowalski; Lee; White; Kimble Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3580 - 3594

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Citation Number: 33

Abstract

A series of chromene derivatives was synthesized and evaluated for their in vitro and ex vivo 5-lipoxygenase (&LO) inhibitory activity. These compounds were prepared by condensation of appropriate salicyl aldehydes with a, P-unsaturated carbonyl compounds, followed by transformation to the corresponding hydroxamic acids or N-hydroxyureas. Placement of phenoxy or p-fluorophenoxy substituents at the 6 position of the chromene ring led to a ...