Asymmetric Synthesis of β??Adrenergic Blockers through Multistep One??Pot Transformations Involving In Situ Chiral Organocatalyst Formation

S Wei, R Messerer, SB Tsogoeva

Index: Wei, Shengwei; Messerer, Regina; Tsogoeva, Svetlana B. Chemistry - A European Journal, 2011 , vol. 17, # 51 p. 14380 - 14384

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Citation Number: 18

Abstract

One-pot multistep operations involving organocatalysis are among the most recent, elegant, economically most attractive and sustainable methods in modern synthetic chemistry.[1] Whereas successful examples of one-pot organocatalytic methods [1, 2](and in particular those leading to chiral drugs or their intermediates [3]) rely on the use of organocatalysts synthesized in advance (Scheme 1a), to the best of our knowledge, no one-pot multistep ...

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