An efficient and simple method for synthesis of 2, 2-disubstituted-2H-chromenes by condensation of a phenol with a 1, 1-disubstituted propargyl alcohol using BF 3· Et …
S Madabhushi, R Jillella, KR Godala, KKR Mallu…
Index: Madabhushi, Sridhar; Jillella, Raveendra; Godala, Kondal Reddy; Mallu, Kishore Kumar Reddy; Beeram, China Ramanaiah; Chinthala, Narsaiah Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5275 - 5279
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Citation Number: 14
Abstract
2,2-Disubstituted-2H-chromenes or 2,2-disubstituted-2H-1-benzopyrans are found as a parent structure in natural products 1 and also in many biologically active molecules, which include antitumor, 2 anti-HIV, 3 antibacterial, 4 and antifungal agents. 5 In addition, 2,2-dimethyl-2H- chromenes have high importance as intermediates for the manufacture of several pharmaceutical compounds 6 and 2,2-diaryl-2H-chromenes have applications as photochromic agents. 7 ...
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