Total synthesis of ecteinascidin 743

A Endo, A Yanagisawa, M Abe, S Tohma…

Index: Endo, Atsushi; Yanagisawa, Arata; Abe, Masanao; Tohma, Shigemitsu; Kan, Toshiyuki; Fukuyama, Tohru Journal of the American Chemical Society, 2002 , vol. 124, # 23 p. 6552 - 6554

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Citation Number: 240

Abstract

Ecteinascidin 743 1 (Et 743, 1) is an extremely potent antitumor agent isolated from a marine tunicate, Ecteinascidia turbinata. Et 743 is currently undergoing phase II clinical trials and also attracting considerable attention owing to its unique mechanism of action. 2 The novelty of its structure, the remarkable biological activities, and its natural scarcity make it an attractive target for total synthesis. 3 To date, Corey and co-workers have reported the only total synthesis ...