Synthesis of 2??dialkylaminomethyl??1, 4??benzoxathians

…, US Shah, HB Bhargava, RG Zaylskie…

Index: Tsai; Shah; Bhargava; Zaylskie; Shelver Journal of pharmaceutical sciences, 1972 , vol. 61, # 2 p. 228 - 231

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Citation Number: 5

Abstract

Abstract Some sulfur analogs of 2-dialkylaminomethyl-1, 4-benzo-dioxans were synthesized and evaluated as aL-adrenergic blocking agents to observe the effect of substitution of sulfur for oxygen on adrenolytic activity. Reaction of 2-hydroxybenzenethiol with dialkyl-2, 3- dibromopropylamines resulted in the formation of 2-dialkylaminotnethyl-1, 4-benzoxathians. The structure of these compounds was proven by the use of NMR spectroscopy. In an ...